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Medical terminology · Endocrinology

Multiple Endocrine Neoplasia Type 1

MeSH — National Library of Medicine · Retrieved 2026-10-13

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 1

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Reference details

MeSH descriptor
D018761
Vocabulary edition
2026
Tree positions
C04.588.322.400.500; C04.651.600.500; C04.700.630.500; C16.320.700.630.500; C19.344.400.500

Scope and definition

A form of multiple endocrine neoplasia that is characterized by the combined occurrence of tumors in the PARATHYROID GLANDS, the PITUITARY GLAND, and the PANCREATIC ISLETS. The resulting clinical signs include HYPERPARATHYROIDISM; HYPERCALCEMIA; HYPERPROLACTINEMIA; CUSHING DISEASE; GASTRINOMA; and ZOLLINGER-ELLISON SYNDROME. This disease is due to loss-of-function of the MEN1 gene, a tumor suppressor gene (GENES, TUMOR SUPPRESSOR) on CHROMOSOME 11 (Locus: 11q13).

Entry terms and synonyms

Multiple Endocrine Neoplasia Type 1 Multiple Endocrine Neoplasia Type I Neoplasms, Multiple Endocrine Type I Neoplasms, Multiple Endocrine Type 1 Neoplasia, Multiple Endocrine Type 1 Multiple Endocrine Neoplasms Type 1 Wermer Syndrome

Classification tree positions

C04.588.322.400.500 C04.651.600.500 C04.700.630.500 C16.320.700.630.500 C19.344.400.500

Sources and reuse

Medical vocabulary definition and classification record.
Retrieved: 2026-10-13. Text has been organized for reading; this import has not been independently reviewed by a clinician. It is not individualized medical advice.
Courtesy of the U.S. National Library of Medicine. DrugChat is independent and is not endorsed by NLM.

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