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Laron Syndrome

MeSH — National Library of Medicine · Retrieved 2026-10-13

An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.

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Reference details

MeSH descriptor
D046150
Vocabulary edition
2026
Tree positions
C05.116.099.343.679; C16.320.240.750; C19.297.656

Scope and definition

An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR I by GROWTH HORMONE. Laron syndrome is not a form of primary pituitary dwarfism (GROWTH HORMONE DEFICIENCY DWARFISM) but the result of mutation of the human GHR gene on chromosome 5.

Entry terms and synonyms

Laron Syndrome Syndrome, Laron Growth Hormone Receptor Defect Growth Hormone Receptor Deficiency Laron Dwarfism Dwarfism, Laron Laron Type Dwarfism I Growth Hormone Insensitivity Syndrome Primary Growth Hormone Resistance Severe GH Insensitivity Pituitary Dwarfism II Dwarfism II, Pituitary Dwarfism IIs, Pituitary Pituitary Dwarfism IIs Primary GH Resistance GH Resistance, Primary

Classification tree positions

C05.116.099.343.679 C16.320.240.750 C19.297.656

Sources and reuse

Medical vocabulary definition and classification record.
Retrieved: 2026-10-13. Text has been organized for reading; this import has not been independently reviewed by a clinician. It is not individualized medical advice.
Courtesy of the U.S. National Library of Medicine. DrugChat is independent and is not endorsed by NLM.

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