Health topic · Oncology

Melanoma

MedlinePlus, National Library of Medicine · Retrieved 2026-10-13

Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal, or "ugly looking." Thinking of "ABCDE" can help you remember what to watch for: • Asymmetry - the shape of one half does not match the other • Border - the edges are ragged, blurred or irregular • Color - the color is…

View original source ↗

Reference details

MedlinePlus topic groups
Cancers; Skin, Hair and Nails
MeSH terms
Melanoma
XML release date
10/13/2026 02:30:36

Overview

Melanoma is the most serious type of skin cancer. Often the first sign of melanoma is a change in the size, shape, color, or feel of a mole. Most melanomas have a black or black-blue area. Melanoma may also appear as a new mole. It may be black, abnormal, or "ugly looking." Thinking of "ABCDE" can help you remember what to watch for: • Asymmetry - the shape of one half does not match the other • Border - the edges are ragged, blurred or irregular • Color - the color is uneven and may include shades of black, brown and tan • Diameter - there is a change in size, usually an increase • Evolving - the mole has changed over the past few weeks or months Surgery is the first treatment of all stages of melanoma. Other treatments include chemotherapy and radiation, biologic, and targeted therapies. Biologic therapy boosts your body's own ability to fight cancer. Targeted therapy uses substances that attack cancer cells without harming normal cells. NIH: National Cancer Institute

Sources and reuse

Original source summary. Follow the source links for additional information.
Retrieved: 2026-10-13. Text has been organized for reading; this import has not been independently reviewed by a clinician. It is not individualized medical advice.
Courtesy of the U.S. National Library of Medicine. DrugChat is independent and is not endorsed by NLM.

Related references in Oncology

Medical terminology Oncology

Mongolian Spot

A bluish-gray to gray-brown benign, melanocytic nevus found usually in the LUMBOSACRAL REGION of dark-skinned people, especially those of East Asian ancestry. It is usually congenital or appears shortly after birth, and disappears in…

Medical entity reference Oncology

Mongolian spot

Benign, flat, congenital birthmark, prevalent among East, South, Southeast, North and Central Asian peoples, Indigenous Oceanians, and Amerindians. Wikidata entity Q1072716; linked MeSH descriptor D049328. Includes multilingual names…

Genetics reference Oncology

Breast cancer

Breast cancer is a disease in which certain cells in the breast become abnormal and multiply uncontrollably to form a tumor. Although breast cancer is much more common in women, this form of cancer can also develop in men. In both…

MedlinePlus GeneticsRead reference →